Cortagen (20mg) For Sale

Cortagen Peptide Description

Cortagen (Ala-Glu-Asp-Pro) is a tetrapeptide member of the Khavinson peptide bioregulator family, a group of short peptides typically consisting of 2-4 amino acids. These peptides are known for their powerful bioregulatory effects and their ability to influence gene expression in tissue-specific ways. Cortagen shows significant neuronoprotective and regenerative properties, particularly in the context of nerve injury, and it may also have implications for cardiovascular health.

Peptide Information

Cortagen Research

Cortagen exhibits promising neuronoprotective and nerve regeneration properties, with potential applications in neurotrophic therapies. Its ability to modulate gene expression in the heart also suggests broader therapeutic implications, particularly in cardiovascular health. However, its effects on immunity and hemostasis appear limited compared to similar peptides. Further research is needed to fully understand the mechanisms and potential clinical applications of cortagen.

Neuronoprotective Effects

Cortagen has been shown to exhibit neuronoprotective properties. Studies have demonstrated that cortagen can modulate neuronal activity by affecting the resting potential and action potential of neurons. Specifically, cortagen hyperpolarizes neurons and reduces their spontaneous activity, indicating its activating and neuronoprotective action.¹

Role in Nerve Regeneration

Cortagen has been investigated for its role in nerve regeneration, particularly in the context of peripheral nerve injuries. Research involving rat models has shown that cortagen can stimulate the growth of nerve fibers during the initial stages of regeneration. However, its effects on the conductivity of regenerating nerve fibers were not significant, as measured by compound action potentials. The peptide did not notably affect the conduction velocity of action potentials through the suture site of injured nerves, suggesting that its primary benefits may lie in the early stages of nerve repair.²

Gene Expression and Cardiovascular Effects

Cortagen has also been studied for its impact on gene expression, particularly in the heart. Microarray analyses have revealed that cortagen can significantly alter the expression of numerous genes in the heart, which may contribute to its therapeutic effects. These changes in gene expression suggest potential benefits in cardiovascular and cerebrovascular health, although the specific mechanisms remain to be fully elucidated.³

Immunity and Hemostasis

In studies involving hypophysectomized chickens and older birds, cortagen did not significantly affect parameters related to erythrocytes, immunity, and hemostasis. This contrasts with another tetrapeptide, epithalon, which was effective in eliminating shifts in these parameters. The difference in terminal amino acids between cortagen and epithalon may account for their differing effects on these physiological systems.⁴

Certificate of Analysis (COA) for Every Batch

A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

• High-performance liquid chromatography (HPLC) for purity, typically confirmed at 99% or higher
• Liquid chromatography mass spectrometry (LC-MS) for molecular identity and mass confirmation
• Sterility and endotoxin screening where applicable
• Chemical contaminant and residual solvent checks

COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.